{"id":12065,"date":"2023-03-01T01:00:53","date_gmt":"2023-03-01T01:00:53","guid":{"rendered":"https:\/\/ultimatehealthreport.com\/thc-and-cbd-rich-cannabis-for-fibromyalgia\/"},"modified":"2023-03-01T01:00:53","modified_gmt":"2023-03-01T01:00:53","slug":"thc-and-cbd-rich-cannabis-for-fibromyalgia","status":"publish","type":"post","link":"https:\/\/ultimatehealthreport.com\/thc-and-cbd-rich-cannabis-for-fibromyalgia\/","title":{"rendered":"THC and CBD-Rich Cannabis for Fibromyalgia"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div property=\"content:encoded\">\n<p>For all modern medicine can do, many mysteries remain unsolved. What is long <span class=\"caps\">COVID<\/span>? Is there really such thing as a \u201ccure\u201d for cancer? And how to explain the surprisingly high prevalence of fibromyalgia, a debilitating, lifelong disorder of the central nervous system without a known cause that affects between 2 and 4 percent of adults worldwide?<\/p>\n<p>In the absence of an answer \u2013 or a cure \u2013 treatment is the name of the game for fibromyalgia. No single drug yet exists to address all of the disease\u2019s effects on the body, which can include widespread aches and pains, sleeplessness, fatigue, anxiety, and depression. Instead, patients turn to a mix of whatever individual medications, therapies, and lifestyle changes (especially exercise) help ease symptoms and improve quality of life.<\/p>\n<p>On the drug front, anti-depressants, analgesics, and muscle relaxants might be prescribed. But there\u2019s another option that can address mood, pain, and more at once, all with fewer side effects: cannabis.<\/p>\n<p>It\u2019s not a new idea. Researchers have been investigating the use of cannabis to treat fibromyalgia\u2019s constellation of symptoms for decades, with early clinical trials in the 2000s<sup id=\"fnref:1\">1<\/sup><sup id=\"fnref:2\">2<\/sup><sup id=\"fnref:3\">3<\/sup><sup id=\"fnref:4\">4<\/sup> suggesting a possible benefit of both pure <span class=\"caps\">THC<\/span> and flower in managing the disease. Nor is it necessarily surprising, given the ability of cannabis to target the ubiquitous, homeostasis-seeking endocannabinoid system.<\/p>\n<p>Recently published papers \u2013 a series of reviews, two human studies, and an animal study \u2013 only bolster the case that cannabis can help those suffering from this confounding condition. Still more may be forthcoming, including through a newly announced randomized controlled trial in the Netherlands that will compare cannabis, oxycodone, and a combination of the two for pain relief in 60 fibromyalgia patients.<sup id=\"fnref:5\">5<\/sup><\/p>\n<div class=\"callout\"><\/div>\n<h2>Solid Evidence Base<\/h2>\n<p>Over the last few months a number of reviews have helped refine our understanding of the relationship between cannabis, the endocannabinoid system (<span class=\"caps\">ECS<\/span>), and fibromyalgia symptoms. In November 2022, a paper in the journal <em>Pain Reports<\/em><sup id=\"fnref:6\">6<\/sup> provided the first systematic review and meta-analysis of previous studies measuring levels of circulating endocannabinoids and other fatty acid derivatives in patients with both fibromyalgia and chronic widespread pain.<\/p>\n<p>Across the eight studies they analyzed, the Australia-based authors identified increased levels of oleoylethanolamide and stearoylethanolamide (endocannabinoid-like molecules called N-Acylethanolamines that don\u2019t bind with the cannabinoid receptors) in patients with these conditions compared to controls. There were no differences observed in levels of the endocannabinoids anandamide and 2-<span class=\"caps\">AG<\/span>.<\/p>\n<aside class=\"pull-right\">\n<p>\u201cAvailable data strongly support the use of cannabinoids in treating fibromyalgia pain\u201d due to \u201coverwhelmingly positive treatment results.\u201d<\/p>\n<\/aside>\n<p>Still, the authors caution that \u201cmost studies did not account for variables that may influence <span class=\"caps\">ECS<\/span> function, including cannabis use, concomitant medication, comorbidities, physical activity, stress levels, circadian rhythm, sleep quality, and dietary factors.\u201d They call for additional study in this area and, more broadly, seek to \u201chighlight the importance of investigating endocannabinoid activity in chronic widespread pain and fibromyalgia because it will underpin future translational research in the area.\u201d<\/p>\n<p>Other recent papers summarize the state of the science:<\/p>\n<ul>\n<li>A review of clinical and preclinical research into cannabinoids, the <span class=\"caps\">ECS<\/span>, and fibromyalgia in <em>Pharmacology <span class=\"amp\">&amp;<\/span> Therapeutics<\/em><sup id=\"fnref:7\">7<\/sup> (December 2022) agreed that \u201cthere is evidence for alterations in the endocannabinoid system in patients with fibromyalgia.\u201d<\/li>\n<li>A systematic review and meta-analysis of eight studies investigating the benefits of cannabinoids for chronic pain in <em>Pain and Therapy<\/em><sup id=\"fnref:8\">8<\/sup> (December 2022) reported that \u201ccannabinoids might improve pain and quality of life in patients with fibromyalgia.\u201d<\/li>\n<li>And a narrative review also in <em>Pain and Therapy<\/em><sup id=\"fnref:9\">9<\/sup> (January 2023) on the efficacy, risks, and benefits of cannabinoids in the treatment of various pain subtypes concluded that \u201cavailable data strongly support the use of cannabinoids in treating fibromyalgia pain\u201d due to \u201coverwhelmingly positive treatment results.\u201d<\/li>\n<\/ul>\n<h2>Mice Respond to Cannabis Oil<\/h2>\n<p>Unlike some other areas of cannabinoid science, fibromyalgia research is not dominated by preclinical laboratory studies. But an October 2022 paper in Biomedicine and Pharmacotherapy10 offers an interesting parallel to previous human studies through the use of a well-established mouse model of fibromyalgia induced by reserpine, a drug that acts on the central nervous system (and is sometimes used to treat high blood pressure in humans).<\/p>\n<p>The Italy- and Brazil-based authors sought to evaluate the effect of a \u201cbroad-spectrum\u201d 11:1 <span class=\"caps\">CBD<\/span>:<span class=\"caps\">THC<\/span> cannabis oil in mice with reserpine-induced fibromylagia. They report that oral feeding of a single dose of cannabis oil was enough to mitigate some hallmarks of the condition in mice. Better yet, repeated administration over the course of two weeks reversed reserpine-induced mechanical and thermal sensitivity, and also reduced depressive-like behavior.<\/p>\n<p>While the implications of these findings for human physiology and disease are perhaps unclear \u2013 given that we still don\u2019t fully understand the etiology of fibromyalgia \u2013 they appear to lend yet more credibility to cannabis.<\/p>\n<div class=\"callout\"><img fetchpriority=\"high\" decoding=\"async\" typeof=\"foaf:Image\" class=\"img-responsive\" src=\"https:\/\/www.projectcbd.org\/sites\/projectcbd\/files\/styles\/related_content_popout\/public\/field\/image\/quick-hits\/fibromyalgia-cannabis-m.png?itok=UAPGUTob\" width=\"670\" height=\"350\" alt=\"\" data-pagespeed-url-hash=\"685368385\" onload=\"pagespeed.CriticalImages.checkImageForCriticality(this);\"\/><\/div>\n<h2>Cannabis Helps \u201cTreatment-Resistant\u201d Patients<\/h2>\n<p>Two new prospective cohort studies build upon this work with additional real-world data that may well wind up in future reviews. A November 2022 article in the journal Pain Practice<sup id=\"fnref:11\">11<\/sup> covers a clinical trial in which 30 women suffering from fibromyalgia symptoms resistant to traditional pharmacological treatments were provided medicinal cannabis. That seemed to make all the difference. Comparing the women\u2019s scores on the World Health Organization Quality of Life questionnaire before and after a month of cannabis use revealed \u201ca marked improvement in general quality of life, general health, physical health, and psychological domain.\u201d<\/p>\n<p>And a similar, earlier study by researchers in Canada \u2013 with 323 fibromyalgia patients followed for 12 months \u2013 also found through quarterly physician assessments that initiating cannabis use was associated with improvements on a variety of fronts. As the authors report in the journal Arthritis Care <span class=\"amp\">&amp;<\/span> Research,<sup id=\"fnref:12\">12<\/sup> observed reductions in pain intensity appeared to be partly explained by concurrent benefits to both sleep and mood.<\/p>\n<p>\u201cWith suboptimal response to current medications, many patients with fibromyalgia seek \u2026 cannabis,\u201d the authors conclude. \u201cMedical cannabis may present a useful treatment strategy for patients with fibromyalgia in light of an effect on the triad of symptoms of pain, negative affect, and sleep disturbances.\u201d<\/p>\n<hr\/>\n<p><em><em>Nate Seltenrich, an independent science journalist based in the San Francisco Bay Area, covers a wide range of subjects including environmental health, neuroscience, and pharmacology. Copyright, Project <span class=\"caps\">CBD<\/span>. May not be reprinted without permission.<\/em><\/em><\/p>\n<hr\/>\n<h2>Footnotes<\/h2>\n<p>\u00a0<\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.projectcbd.org\/thc-and-cbd-rich-cannabis-fibromyalgia\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For all modern medicine can do, many mysteries remain unsolved. What is long COVID? Is there really such thing as a \u201ccure\u201d for cancer? And [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[35],"tags":[],"_links":{"self":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/12065"}],"collection":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/comments?post=12065"}],"version-history":[{"count":0,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/12065\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media\/12066"}],"wp:attachment":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media?parent=12065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/categories?post=12065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/tags?post=12065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}