{"id":12712,"date":"2023-04-10T23:24:37","date_gmt":"2023-04-10T23:24:37","guid":{"rendered":"https:\/\/ultimatehealthreport.com\/tiny-cylinders-for-controlled-drug-release\/"},"modified":"2023-04-10T23:24:37","modified_gmt":"2023-04-10T23:24:37","slug":"tiny-cylinders-for-controlled-drug-release","status":"publish","type":"post","link":"https:\/\/ultimatehealthreport.com\/tiny-cylinders-for-controlled-drug-release\/","title":{"rendered":"Tiny Cylinders for Controlled Drug Release"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<figure class=\"wp-block-image size-full\"><noscript><img fetchpriority=\"high\" decoding=\"async\" width=\"770\" height=\"514\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cilynders-on-slide.jpg\" alt=\"\" class=\"wp-image-1547823\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cilynders-on-slide.jpg 770w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cilynders-on-slide-300x200.jpg 300w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cilynders-on-slide-768x513.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\"\/><\/noscript><\/figure>\n<p>Researchers at Rice University have developed a new type of microparticle for drug delivery, made from a polymer called PLGA that has already been extensively explored as a component in drug delivery systems. However, what makes these new particles different is the method of loading and sealing them, which appears to give them highly tunable release characteristics and may even allow the researchers to create particles that provide multiple doses of a drug, or continuous dosing, over the space of several months. The researchers have called their new particle creation method PULSED (Particles Uniformly Liquified and Sealed to Encapsulate Drugs), and it involves 3D printing and soft lithography to produce arrays of particles that can be loaded with drugs.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"466\" height=\"603\" data-lazy-type=\"image\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders.jpg\" alt=\"\" class=\"lazy lazy-hidden wp-image-1547825\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders.jpg 466w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders-232x300.jpg 232w\" data-lazy-sizes=\"(max-width: 466px) 100vw, 466px\"\/><noscript><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"466\" height=\"603\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders.jpg\" alt=\"\" class=\"wp-image-1547825\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders.jpg 466w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/bunch-of-cylinders-232x300.jpg 232w\" sizes=\"(max-width: 466px) 100vw, 466px\"\/><\/noscript><\/figure>\n<\/div>\n<p>While conventional drug treatment is a cornerstone of medicine, it is not without its flaws. Patients frequently forget to take their drugs and it is inconvenient to have to remember to take a pill every day or visit a clinic for multiple rounds of injections. Many people missed their follow-up doses of COVID-19 vaccines, for instance. These issues have prompted researchers to develop time-release drug delivery systems that can take the hard work out of drug treatment.<\/p>\n<p>\u201cThis is a huge problem in the treatment of chronic disease,\u201d said Kevin McHugh, a researcher involved in the study. \u201cIt\u2019s estimated that 50% of people don\u2019t take their medications correctly. With this, you\u2019d give them one shot, and they\u2019d be all set for the next couple of months.\u201d \u00a0<!-- ASYNC UAT M - 300x250(t,r) - --><\/p>\n<p><!-- END ASYNC UAT M - 300x250(t,r) --><\/p>\n<p>The researchers developed a new way to create and seal drug-loaded particles. This involves creating arrays of tiny PLGA cylinders that are small enough to be injected through a standard hypodermic needle and then loading them with a drug before using heat to seal the particles. By changing the PLGA recipe, the researchers can drastically alter the release profile of the encapsulated drug, permitting release from 10 days to as long as five weeks.<\/p>\n<p>The main goal is to avoid all the drug being released too quickly, but rather tune the recipe to allow slow, continuous release. \u201cThe thing we\u2019re trying to overcome is \u2018first-order release,&#8217;\u201d added McHugh. \u201cThe common pattern is for a lot of the drug to be released early, on day one. And then on day 10, you might get 10 times less than you got on day one. \u00a0<\/p>\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"770\" height=\"517\" data-lazy-type=\"image\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up.jpg\" alt=\"\" class=\"lazy lazy-hidden wp-image-1547826\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up.jpg 770w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up-300x201.jpg 300w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up-768x516.jpg 768w\" data-lazy-sizes=\"(max-width: 770px) 100vw, 770px\"\/><noscript><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"770\" height=\"517\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up.jpg\" alt=\"\" class=\"wp-image-1547826\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up.jpg 770w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up-300x201.jpg 300w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/04\/cylinders-close-up-768x516.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\"\/><\/noscript><\/figure>\n<p>While the researchers have managed to achieve drug release over five weeks to date, they are confident that they can further modify the particles to allow them to release drugs for as long as six months. This could be a game changer for patients with complicated drug regimens.<\/p>\n<p>See a video about the technology below.<\/p>\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n<div class=\"wp-block-embed__wrapper\">\n<img decoding=\"async\" class=\"lazy lazy-hidden\" data-lazy-type=\"iframe\" src=\"&lt;iframe loading=&quot;lazy&quot; title=&quot;Rice lab\u2019s tech could deliver time-released drugs, vaccines for months&quot; width=&quot;770&quot; height=&quot;433&quot; bad-src=&quot;https:\/\/www.youtube.com\/embed\/qWE_28gFgxE?feature=oembed&quot; frameborder=&quot;0&quot; allow=&quot;accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share&quot; allowfullscreen&gt;&lt;\/iframe&gt;\" alt=\"\"\/><noscript><iframe title=\"Rice lab\u2019s tech could deliver time-released drugs, vaccines for months\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/qWE_28gFgxE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe><\/noscript>\n<\/div>\n<\/figure>\n<p>Study in journal <em>Advanced Materials<\/em>: A Scalable Platform for Fabricating Biodegradable Microparticles with Pulsatile Drug Release<\/p>\n<p>Via: Rice<\/p>\n<p><!--TrendMD v2.4.8--><\/div>\n<p><script>(function(d, s, id) {\n var js, fjs = d.getElementsByTagName(s)[0];\n if (d.getElementById(id)) return;\n js = d.createElement(s); js.id = id;\n js.src = \"\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&version=v2.4&appId=2624537092\";\n fjs.parentNode.insertBefore(js, fjs);\n}(document, 'script', 'facebook-jssdk'));<\/script><br \/>\n<br \/><br \/>\n<br \/><a href=\"https:\/\/www.medgadget.com\/2023\/04\/tiny-cylinders-for-controlled-drug-release.html\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Rice University have developed a new type of microparticle for drug delivery, made from a polymer called PLGA that has already been extensively [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12714,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[23],"tags":[],"_links":{"self":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/12712"}],"collection":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/comments?post=12712"}],"version-history":[{"count":0,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/12712\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media\/12714"}],"wp:attachment":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media?parent=12712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/categories?post=12712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/tags?post=12712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}