{"id":13415,"date":"2023-05-26T00:25:08","date_gmt":"2023-05-26T00:25:08","guid":{"rendered":"https:\/\/ultimatehealthreport.com\/cell-culture-chamber-mimics-mechanical-states-of-disease\/"},"modified":"2023-05-26T00:25:08","modified_gmt":"2023-05-26T00:25:08","slug":"cell-culture-chamber-mimics-mechanical-states-of-disease","status":"publish","type":"post","link":"https:\/\/ultimatehealthreport.com\/cell-culture-chamber-mimics-mechanical-states-of-disease\/","title":{"rendered":"Cell Culture Chamber Mimics Mechanical States of Disease"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<figure class=\"wp-block-image size-full\"><noscript><img fetchpriority=\"high\" decoding=\"async\" width=\"770\" height=\"524\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/3d-drug-screening-chamber.jpg\" alt=\"\" class=\"wp-image-1548884\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/3d-drug-screening-chamber.jpg 770w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/3d-drug-screening-chamber-300x204.jpg 300w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/3d-drug-screening-chamber-768x523.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\"\/><\/noscript><\/figure>\n<p>Researchers at the University of G\u00f6ttingen in Germany have developed a cell culture chamber that lets them culture tissue samples, mimic the mechanical conditions that tissues experience in various disease states, and closely monitor tissue reactions. The technology could be particularly useful for pre-clinical drug testing, allowing researchers to test the effects of various drug candidates on tissues without the need to use experimental animals. The chamber includes elastic posts to which muscle fibers can attach and pull against, and permits high-resolution microscopy so that the researchers can appraise how the tissue reacts to various stimuli. The G\u00f6ttingen team recently received a grant from the European Union to help them to develop the chamber further.<\/p>\n<p>Researchers are working hard to create new<em> in vitro<\/em> technologies that will streamline and de-risk drug development. At present, the drug development pipeline is fraught with difficulties, expense, and ethical dilemmas, including the use of experimental animals. Reducing the work, time, and expense of bringing new drugs to market could unlock a whole host of much needed new treatments, and advanced <em>in vitro<\/em> tissue culture systems are well poised to play a big role here.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"399\" height=\"722\" data-lazy-type=\"image\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system.png\" alt=\"\" class=\"lazy lazy-hidden wp-image-1548882\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system.png 399w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system-166x300.png 166w\" data-lazy-sizes=\"(max-width: 399px) 100vw, 399px\"\/><noscript><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" width=\"399\" height=\"722\" src=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system.png\" alt=\"\" class=\"wp-image-1548882\" srcset=\"https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system.png 399w, https:\/\/medgadget.wpenginepowered.com\/wp-content\/uploads\/2023\/05\/chamber-system-166x300.png 166w\" sizes=\"(max-width: 399px) 100vw, 399px\"\/><\/noscript><\/figure>\n<\/div>\n<p>This latest technology is a cell culture chamber that allows for advanced tissue culture and manipulation, including mimicking the mechanical conditions that tissues experience in various disease states, such as cardiovascular disease. The chamber is a work in progress, and new EU funding is intended to assist the researchers to bring it to fruition, where it will include optical fiber technology to perform motion and force measurements and piezo-based actuators to impart mechanical forces on tissue samples.<!-- ASYNC UAT M - 300x250(t,r) - --><\/p>\n<p><!-- END ASYNC UAT M - 300x250(t,r) --><\/p>\n<p>\u201cOur new research project sets out to develop a system to enable automated functional screening of the effects of a compound on human tissue,\u201d said Timo Betz, one of the developers of the new device. \u201cIt also means that scientists will be able to model different health conditions in the lab to get a better understanding of disease processes and treatments. This could be a game changer for the pharmaceutical industry as well as academic and medical research.\u201d<\/p>\n<p>The mechanical monitoring that the system can perform could be very useful for studying diseases that involve muscle wasting, such as muscular dystrophies, allowing researchers to directly measure the effect of various therapeutic molecules on muscle tissue strength and structure.<\/p>\n<p>Via: University of G\u00f6ttingen<\/p>\n<p><!--TrendMD v2.4.8--><\/div>\n<p><script>(function(d, s, id) {\n var js, fjs = d.getElementsByTagName(s)[0];\n if (d.getElementById(id)) return;\n js = d.createElement(s); js.id = id;\n js.src = \"\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&version=v2.4&appId=2624537092\";\n fjs.parentNode.insertBefore(js, fjs);\n}(document, 'script', 'facebook-jssdk'));<\/script><br \/>\n<br \/><br \/>\n<br \/><a href=\"https:\/\/www.medgadget.com\/2023\/05\/cell-culture-chamber-mimics-mechanical-states-of-disease.html\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of G\u00f6ttingen in Germany have developed a cell culture chamber that lets them culture tissue samples, mimic the mechanical conditions that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13416,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[23],"tags":[],"_links":{"self":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/13415"}],"collection":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/comments?post=13415"}],"version-history":[{"count":0,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/13415\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media\/13416"}],"wp:attachment":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media?parent=13415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/categories?post=13415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/tags?post=13415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}