Transcript<\/span><\/h3>\nProject CBD<\/span>:<\/strong> I\u2019m Martin Lee with Project CBD<\/span>, and today we\u2019re speaking with Dr. Ethan Russo, a neurologist and past president of the International Cannabinoid Research Society. Dr. Russo was also formerly the chief medical director of GW<\/span> Pharmaceuticals and in that capacity he was involved in developing the drug called Sativex, which is now approved in, I think two dozen countries \u2013 but not in the United States. It\u2019s a formulation including both CBD<\/span> and THC<\/span>. And Dr. Russo was also involved in research that culminated in the FDA<\/span>\u2019s approval of Epidiolex, a CBD<\/span> pharmaceutical that\u2019s now prescribed for three different pediatric seizure disorders. Currently, Dr. Russo is the founder and CEO<\/span> of CR<\/span>eDO Science, and we\u2019re going to be speaking a little more about that in this conversation. You for joining us, Ethan.<\/em><\/p>\nDr. Russo:<\/strong> Thank you. A pleasure to be here.<\/p>\nProject CBD<\/span>: <\/em><\/strong>Today we\u2019re going to discuss an article you co-authored that was recently published in the journal Cannabis and Cannabis Research. The article focused on a phenomenon known as Cannabis Hyperemesis Syndrome. Maybe you can start by explaining what is syndrome?<\/em><\/p>\nDr. Russo:<\/strong> Sure. Well properly speaking it\u2019s called Cannabinoid Hyperemesis Syndrome [or CHS<\/span>] because it actually can occur with synthetic cannabinoids \u2013 anything where there is a chronic high potency exposure to the CB1<\/span> [cannabinoid] receptor. So what is Cannabinoid Hyperemesis Syndrome? It\u2019s a constellation of unusual circumstances that heretofore has been of enigmatic origin. It consists of nausea, vomiting, abdominal pain, and a strange behavior of hot water baths or showers that seem to alleviate symptoms. This was first reported in 2004, but the index patient went back to 1996. This was in Australia. Subsequently it\u2019s been found all over the world, but nowhere more prevalently then in the US<\/span>, as you might imagine, given the pre-eminence of the United States in the development of higher-potency cannabis chemovars, and particularly concentrates.<\/p>\nProject CBD<\/span>:<\/strong> I\u2019m a little bit confused about something: When I think of cannabis or cannabinoids, I think of something that actually helps nausea in the context of the medical cannabis phenomenon in the United States that emerged legally in the 1990s. I think that was one of the main conditions for which cannabis was helpful. You\u2019re saying that, in this case, it\u2019s just the opposite. Maybe you can shed some light on that contradiction.<\/em><\/p>\n