{"id":474,"date":"2021-07-23T05:32:32","date_gmt":"2021-07-23T05:32:32","guid":{"rendered":"https:\/\/ultimatehealthreport.com\/nanoparticles-for-tumor-imaging-and-cancer-urine-testing\/"},"modified":"2021-07-23T05:32:32","modified_gmt":"2021-07-23T05:32:32","slug":"nanoparticles-for-tumor-imaging-and-cancer-urine-testing","status":"publish","type":"post","link":"https:\/\/ultimatehealthreport.com\/nanoparticles-for-tumor-imaging-and-cancer-urine-testing\/","title":{"rendered":"Nanoparticles for Tumor Imaging and Cancer Urine Testing"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<p>Scientists at MIT have announced that they developed novel nanoparticles to detect cancer in urine samples. As well as detecting the presence of tumors, the nanoparticles can also accumulate at tumor sites and function as an imaging agent, helping to identify their location. These multifunctional particles could be very useful for routine cancer screening and helping clinicians to determine whether a tumor has spread or recurred.<\/p>\n<p>\u201cThis is a really broad sensor intended to respond to both primary tumors and their metastases,\u201d said Sangeeta Bhatia, a researcher involved in the study. \u201cIt can trigger a urinary signal and also allow us to visualize where the tumors are.\u201d<\/p>\n<figure class=\"wp-block-image size-large\"><noscript><img decoding=\"async\" src=\"https:\/\/www.medgadget.com\/wp-content\/uploads\/2021\/07\/tumor-nodule.jpg\" alt=\"\" class=\"wp-image-1516189\" srcset=\"https:\/\/www.medgadget.com\/wp-content\/uploads\/2021\/07\/tumor-nodule.jpg 770w, https:\/\/www.medgadget.com\/wp-content\/uploads\/2021\/07\/tumor-nodule-300x200.jpg 300w, https:\/\/www.medgadget.com\/wp-content\/uploads\/2021\/07\/tumor-nodule-768x512.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\"\/><\/noscript><\/figure>\n<p>The nanoparticles are covered with peptides that can be naturally cleaved by proteases present on the surface of cancer cells. These cleaved peptides end up in the urine to form a synthetic biomarker where they can be detected through a simple urine test. The researchers have already tested the nanoparticles in animal models of cancer, and they successfully highlighted the presence of tumors.<!-- ASYNC UAT M - 300x250(t,r) - --><\/p>\n<p><!-- END ASYNC UAT M - 300x250(t,r) --><\/p>\n<p>So far, so good, but clinicians need to know where exactly the tumors are, and if they spread to multiple sites in the body. Happily, the nanoparticles also function as a tumor imaging agent. The researchers included the radioactive agent copper-64 within the particles, which can be detected using PET (positron emission tomography) imaging. The particles\u2019 surface is also studded with peptides that are attracted to the acidic tumor microenvironment, helping to enhance particle accumulation and retention within tumors.<\/p>\n<p>The researchers have high hopes that the system could be very useful for long-term monitoring of cancer patients. \u201cThose patients could be monitored with the urinary version of the test every six months, for instance,\u201d said Bhatia. \u201cIf the urine test is positive, they could follow up with a radioactive version of the same agent for an imaging study that could indicate where the disease had spread. We also believe the regulatory path may be accelerated with both modes of testing leveraging a single formulation.\u201d<\/p>\n<p>Excitingly, the system may even serve as a cancer test . \u201cThe vision is that you could use this in a screening paradigm \u2013 alone or in conjunction with other tests \u2013 and we could collectively reach patients that do not have access to costly screening infrastructure today,\u201d said Bhatia. \u201cEvery year you could get a urine test as part of a general check-up. You would do an imaging study only if the urine test turns positive to then find out where the signal is coming from. We have a lot more work to do on the science to get there, but that\u2019s where we would like to go in the long run.\u201d<\/p>\n<p>Study in <em>Nature Materials<\/em>: Microenvironment-triggered multimodal precision diagnostics<\/p>\n<p>Via: MIT<\/p>\n<p><!--TrendMD v2.4.8--><\/div>\n<p><script>(function(d, s, id) {\n var js, fjs = d.getElementsByTagName(s)[0];\n if (d.getElementById(id)) return;\n js = d.createElement(s); js.id = id;\n js.src = \"https:\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&version=v2.4&appId=2624537092\";\n fjs.parentNode.insertBefore(js, fjs);\n}(document, 'script', 'facebook-jssdk'));<\/script><br \/>\n<br \/><br \/>\n<br \/><a href=\"https:\/\/www.medgadget.com\/2021\/07\/nanoparticles-for-tumor-imaging-and-cancer-urine-testing.html\" target=\"_blank\" rel=\"noopener\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at MIT have announced that they developed novel nanoparticles to detect cancer in urine samples. As well as detecting the presence of tumors, the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[23],"tags":[],"_links":{"self":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/474"}],"collection":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/comments?post=474"}],"version-history":[{"count":0,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/posts\/474\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media\/475"}],"wp:attachment":[{"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/media?parent=474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/categories?post=474"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ultimatehealthreport.com\/wp-json\/wp\/v2\/tags?post=474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}